Yes. Unreal's Paper 2D tools support sprite-based games, including side-scrolling platformers. Start with one character, one floor and one jump. A 2D game still runs in Unreal's three-dimensional world, so the camera, movement plane and collision geometry need to agree. Fixing those relationships early prevents characters that appear to stand on a platform but actually pass behind it.
Turn art into an animated character
Enable the Paper 2D plug-in if it is not already enabled, then restart when prompted. Import art as sprites. Use flipbooks to group animation frames into idle and running sequences. Choose a consistent pixels-per-unit scale and align the foot pivot across frames. If the hero bobs while standing still, inspect the pivots before changing physics settings. A sprite is one visual asset; a flipbook sequences several sprites over time.
Align the camera with movement
Use a PaperCharacter or an appropriate character Blueprint with a movement component. For a side view moving along X and Z, constrain movement to that plane and point the camera along the depth axis. An orthographic camera is a useful starting choice when objects should keep the same apparent size. Set its width so players can see the next jump. A perspective camera can work for a layered 2.5D look, but depth changes the framing.
Test collision separately from the picture
Use a simple collision shape for the floor and the character's capsule for movement. Show collision in the editor and compare what the player sees with what the physics system sees. Test standing, jumping into the underside of a platform and landing near its edge. Then test changing between idle and run without shifting the collision body. Package the tiny level before you commit to a large tile set, elaborate lighting or a long campaign.
For the documented workflow, see Paper 2D example.
Common Questions
Do I have to write C++?
Blueprints can handle a small platformer.
Do I need a Tile Map?
No. Simple platforms are sufficient for a first level.
Can 2D characters share a 3D scene?
Yes. Camera direction and depth ordering become important.
Why does my sprite look blurry?
Inspect texture filtering, scaling and camera framing at the intended resolution.